교수소개
교수소개
2009.03 - 2011.08 부경대학교 화학과, 박사
2007.03 - 2009.02 부경대학교 화학과, 석사
2002.03 - 2007.02 부경대학교 화학과, 학사
2022 - 현재 부경대학교, 식품영양학과, 부교수
2017 - 2022 제주대학교, 수산생명의학과, 학술연구교수
2016 - 2016 퀸즐랜드대학교 (The University of Queensland, Qld, AU), Institute for Molecular Bioscience, 전임염구원 (Research Officer)
2013 - 2015 퀸즐랜드대학교 (The University of Queensland, Qld, AU), 약학대학, 박사후연구원 (UQ Postdoctoral Research Fellowships 2013-2015)
2011 - 2012 부경대학교, 화학과, 전임연구원 (학문후속세대양성2011-2012)
식품소재 유래 기능성 구성성분 탐색 및 영양학적 기전 연구
수산식품유래 건강기능성 식품소재 개발 및 산업화 지원 연구
유기화학, 생화학 (I, II), 분자생물학, 분자영양학, 생화학실험
연구실적 (논문, 저서, 특허)
논문연구 (2018-2022: 47편, 총 104편)
2. Lee, H. G., Oh, J. Y., Chung, D. M., Seo, M. Y., Park, S. J., Jeon, Y. J., & Ryu, B. M. (2022). Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities. Marine Drugs, 20(6), 346.
3. Ratsch, A., Bogossian, F., Burmeister, E. A., Ryu, B., & Steadman, K. (2022). Higher blood nicotine concentrations following smokeless tobacco (pituri) and cigarette use linked to adverse pregnancy outcomes for central Australian Aboriginal pregnancies.
4. Pei, Y., Cai, S., Ryu, B., Zhou, C., Hong, P., & Qian, Z. J. (2022). An ACE inhibitory peptide from Isochrysis zhanjiangensis exhibits antihypertensive effect via anti-inflammation and anti-apoptosis in HUVEC and hypertensive rats. Journal of Functional Foods, 92, 105061.
5. Yang, H. W., Oh, S., Chung, D. M., Seo, M., Park, S. J., Jeon, Y. J., ... & Ryu, B. (2022). Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo. Marine Drugs, 20(5), 280.
6. Hyun, J., Ryu, B., Oh, S., Chung, D. M., Seo, M., Park, S. J., ... & Jeon, Y. J. (2022). Reversibility of sarcopenia by Ishige okamurae and its active derivative diphloroethohydroxycarmalol in female aging mice. Biomedicine & Pharmacotherapy, 152, 113210.
7. Cho, C. H., Lee, C. J., Kim, M. G., Ryu, B., Je, J. G., Kim, Y., & Lee, S. H. (2022). Therapeutic Potential of Phlorotannin-Rich Ecklonia cava Extract on Methylglyoxal-Induced Diabetic Nephropathy in In Vitro Model. Marine Drugs, 20(6), 355.
8. Ryu, B., Oh, S., Yang, H. W., Sosorburam, B., Chung, D. M., Seo, M., ... & Jeon, Y. J. (2022). Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model. Pharmaceutics, 14(4), 719.
9. Hyun J., Ryu B., Jiang Y., Je J.G., Yang H.W., Yang F.Y., & Jeon Y.J. (2022). Detrimental impact of fine dust on zebrafish: Investigating a protective agent against ocular-damage using in vitro and in vivo models. Chemosphere, 293, 133602.
10. Ryu, B., Je, J. G., Jeon, Y. J., & Yang, H. W. (2021). Zebrafish Model for Studying Dexamethasone-Induced Muscle Atrophy and Preventive Effect of Maca (Lepidium meyenii). Cells, 10(11), 2879.
11. Kim, M., Cho, C., Lee, C., Ryu, B., Kim, S., Hur, J., & Lee, S. H. (2021). Ishige okamurae Ameliorates Methylglyoxal-Induced Nephrotoxicity via Reducing Oxidative Stress, RAGE Protein Expression, and Modulating MAPK, Nrf2/ARE Signaling Pathway in Mouse Glomerular Mesangial Cells. Foods, 10(9), 2000.
12. Ryu, B., Shin, K. H., & Kim, S. K. (2021). Muscle protein hydrolysates and amino acid composition in fish. Marine Drugs, 19(7), 377.
13. Ryu, B., Shin, K. H., & Kim, S. K. (2021). Muscle Protein Hydrolysates and Amino Acid Composition in Fish. Marine Drugs, 19(7), 377.
14. Je, J. G., Lee, H. G., Fernando, K. H., Jeon, Y. J., & Ryu, B. (2021). Purification and Structural Characterization of Sulfated Polysaccharides Derived from Brown Algae, Sargassum binderi: Inhibitory Mechanism of iNOS and COX-2 Pathway Interaction. Antioxidants, 10(6), 822.
15. Yang, H. W., Jiang, Y. F., Lee, H. G., Jeon, Y. J., & Ryu, B. (2021). Ca2+-Dependent Glucose Transport in Skeletal Muscle by Diphlorethohydroxycarmalol, an Alga Phlorotannin: In Vitro and In Vivo Study. Oxidative medicine and cellular longevity, 2021.
16. Hwang, J., Yang, H. W., Lu, Y. A., Je, J. G., Lee, H. G., Fernando, K. H. N., ... & Ryu, B. (2021). Phloroglucinol and dieckol isolated from Ecklonia cava suppress impaired diabetic angiogenesis; A study of in-vitro and in-vivo. Biomedicine & Pharmacotherapy, 138, 111431.
17. Lu, Y. A., Je, J. G., Hwang, J., Jeon, Y. J., & Ryu, B. (2021). Ecklonia cava Extract and Its Derivative Dieckol Promote Vasodilation by Modulating Calcium Signaling and PI3K/AKT/eNOS Pathway in In Vitro and In Vivo Models. Biomedicines, 9(4), 438.
18. Lu, Y. A., Jiang, Y., Yang, H. W., Hwang, J., Jeon, Y. J., & Ryu, B. (2021). Diphlorethohydroxycarmalol Isolated from Ishige okamurae exerts vasodilatory effects via calcium signaling and PI3K/Akt/eNOS pathway. International journal of molecular sciences, 22(4), 1610.
19. Li, X., Yang, H. W., Jiang, Y., Oh, J. Y., Jeon, Y. J., & Ryu, B. (2020). Ishophloroglucin A Isolated from Ishige okamurae Suppresses Melanogenesis Induced by α-MSH: In Vitro and In Vivo. Marine drugs, 18(9), 470.
20. Sanjeewa, K. K., Nagahawatta, D. P., Yang, H. W., Oh, J. Y., Jayawardena, T. U., Jeon, Y. J., ... & Ryu, B. (2020). Octominin inhibits LPS-induced chemokine and pro-inflammatory cytokine secretion from RAW 264.7 macrophages via blocking TLRs/NF-κB signal transduction. Biomolecules, 10(4), 511.
21. Fernando, I. P. S., Ryu, B., Ahn, G., Yeo, I. K., & Jeon, Y. J. (2020). Therapeutic potential of algal natural products against metabolic syndrome: A review of recent developments. Trends in Food Science & Technology, 97, 286-299.
22. Wang, L., Kim, H. S., Oh, J. Y., Je, J. G., Jeon, Y. J., & Ryu, B. (2020). Protective effect of diphlorethohydroxycarmalol isolated from Ishige okamurae against UVB-induced damage in vitro in human dermal fibroblasts and in vivo in zebrafish. Food and Chemical Toxicology, 136, 110963.
23. Wang, L., Oh, J. Y., Jayawardena, T. U., Jeon, Y. J., & Ryu, B. (2020). Anti-inflammatory and anti-melanogenesis activities of sulfated polysaccharides isolated from Hizikia fusiforme. International journal of biological macromolecules, 142, 545-550.
24. Yang, S., Chen, M. F., Ryu, B., Chen, J., Xiao, Z., Hong, P., ... & Zhou, C. (2020). The protective effect of the polysaccharide precursor, D-isofloridoside, from Laurencia undulata on alcohol-induced hepatotoxicity in HepG2 Cells. Molecules, 25(5), 1024.
25. Chen, J., Ryu, B., Zhang, Y., Liang, P., Li, C., Zhou, C., ... & Qian, Z. J. (2020). Comparison of an angiotensinIconverting enzyme inhibitory peptide from tilapia (Oreochromis niloticus) with captopril: inhibition kinetics, in vivo effect, simulated gastrointestinal digestion and a molecular docking study. Journal of the Science of Food and Agriculture, 100(1), 315-324.
26. Sanjeewa, K. A., Fernando, I. P. S., Kim, H. S., Jayawardena, T. U., Ryu, B., Yang, H. W., ... & Jeon, Y. J. (2020). Dieckol: an algal polyphenol attenuates urban fine dust-induced inflammation in RAW 264.7 cells via the activation of anti-inflammatory and antioxidant signaling pathways. Journal of Applied Phycology, 32(4), 2387-2396.
27. Oh, J. Y., Kim, E. A., Kang, S. I., Yang, H. W., Ryu, B., Wang, L., ... & Jeon, Y. J. (2020). Protective effects of fucoidan isolated from celluclast-assisted extract of Undaria pinnatifida sporophylls against AAPH-induced oxidative stress in vitro and in vivo zebrafish model. Molecules, 25(10), 2361.
28. Yang, H. W., Son, M., Choi, J., Oh, S., Jeon, Y. J., Byun, K., & Ryu, B. (2019). Effect of ishophloroglucin A, a component of Ishige okamurae, on glucose homeostasis in the pancreas and muscle of high fat diet-fed mice. Marine drugs, 17(11), 608.
29. Fernando, K. H. N., Yang, H. W., Jiang, Y., Jeon, Y. J., & Ryu, B. (2019). Ishige okamurae extract and its constituent ishophloroglucin a attenuated in vitro and in vivo high glucose-induced angiogenesis. International journal of molecular sciences, 20(22), 5542.
30. Wang, L., Oh, J. Y., Hwang, J., Ko, J. Y., Jeon, Y. J., & Ryu, B. (2019). In vitro and in vivo antioxidant activities of polysaccharides isolated from celluclast-assisted extract of an edible brown seaweed, Sargassum fulvellum. Antioxidants, 8(10), 493.
31. Zhang, Y., Ryu, B., Cui, Y., Li, C., Zhou, C., Hong, P., ... & Qian, Z. J. (2019). A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1α pathway in mice. Journal of Functional Foods, 61, 103489.
32. Ratsch, A., Steadman, K., Ryu, B., & Bogossian, F. (2019). Tobacco and pituri use in pregnancy: a protocol for measuring maternal and perinatal exposure and outcomes in Central Australian Aboriginal women. Methods and protocols, 2(2), 47.
33. Son, M., Oh, S., Lee, H. S., Ryu, B., Jiang, Y., Jang, J. T., ... & Byun, K. (2019). Pyrogallol-phloroglucinol-6, 6’-bieckol from Ecklonia cava improved blood circulation in diet-induced obese and diet-induced hypertension mouse models. Marine drugs, 17(5), 272.
34. Oh, J. Y., Ryu, B., Yang, H. W., Kim, E. A., Lee, J. S., & Jeon, Y. J. (2019). Protective effects of Ecklonia cava extract on the toxicity and oxidative stress induced by hair dye in in-vitro and in-vivo models. Journal of Oceanology and Limnology, 37(3), 909-917.
35. Yang, H. W., Fernando, K. H. N., Oh, J. Y., Li, X., Jeon, Y. J., & Ryu, B. (2019). Anti-obesity and anti-diabetic effects of Ishige okamurae. Marine drugs, 17(4), 202.
36. Fu, J. Q., Chen, Z., Hu, Y. J., Fan, Z. H., Guo, Z. X., Liang, J. Y., Ryu, B.,... & Zhang, C. (2019). A single factor induces neuronal differentiation to suppress glioma cell growth. CNS neuroscience & therapeutics, 25(4), 486-495.
37. Kim, H. S., Je, J. G., Ryu, B., Kang, N., Fernando, I. S., Jayawardena, T. U., ... & Jeon, Y. J. (2019). Antioxidant and angiotensin-I converting enzyme inhibitory peptides from Hippocampus abdominalis. European Food Research and Technology, 245(2), 479-487.
38. Ryu, B., Jiang, Y., Kim, H. S., Hyun, J. M., Lim, S. B., Li, Y., & Jeon, Y. J. (2018). Ishophloroglucin A, a novel phlorotannin for standardizing the anti-α-glucosidase activity of Ishige okamurae. Marine drugs, 16(11), 436.
39. Kim, H. S., Sanjeewa, K. K., Fernando, I. P., Ryu, B., Yang, H. W., Ahn, G., ... & Jeon, Y. J. (2018). A comparative study of Sargassum horneri Korea and China strains collected along the coast of Jeju Island South Korea: its components and bioactive properties. Algae, 33(4), 341-349.
40. Jayawardena, T. U., Sanjeewa, K. A., Fernando, I. S., Ryu, B., Kang, M. C., Jee, Y., ... & Jeon, Y. J. (2018). Sargassum horneri (Turner) C. Agardh ethanol extract inhibits the fine dust inflammation response via activating Nrf2/HO-1 signaling in RAW 264.7 cells. BMC complementary and alternative medicine, 18(1), 1-10.
41. Wang, L., Lee, W. W., Yang, H. W., Ryu, B., Cui, Y. R., Lee, S. C., ... & Jeon, Y. J. (2018). Protective effect of water extract of Citrus pomace against AAPH-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Preventive nutrition and food science, 23(4), 301.
42. Fernando, K. H. N., Yang, H. W., Jiang, Y., Jeon, Y. J., & Ryu, B. (2018). Diphlorethohydroxycarmalol isolated from Ishige okamurae represses high glucose-induced angiogenesis in vitro and in vivo. Marine drugs, 16(10), 375.
43. Wang, L., Lee, W., Oh, J. Y., Cui, Y. R., Ryu, B., & Jeon, Y. J. (2018). Protective effect of sulfated polysaccharides from celluclast-assisted extract of Hizikia fusiforme against ultraviolet B-Induced skin damage by regulating NF-κB, AP-1, and MAPKs signaling pathways in vitro in human dermal fibroblasts. Marine drugs, 16(7), 239.
44. Wang, L., Park, Y. J., Jeon, Y. J., & Ryu, B. (2018). Bioactivities of the edible brown seaweed, Undaria pinnatifida: A review. Aquaculture, 495, 873-880.
45. Vo, T. S., Kim, S. K., Ryu, B., Ngo, D. H., Yoon, N. Y., Bach, L. G., ... & Ngo, D. N. (2018). The suppressive activity of fucofuroeckol-A derived from brown algal Ecklonia stolonifera Okamura on UVB-induced mast cell degranulation. Marine drugs, 16(1), 1.
46. Pathak, M., Coombes, A. G., Ryu, B., Cabot, P. J., Turner, M. S., Palmer, C., ... & Steadman, K. J. (2018). Sustained simultaneous delivery of metronidazole and doxycycline from polycaprolactone matrices designed for intravaginal treatment of pelvic inflammatory disease. Journal of pharmaceutical sciences, 107(3), 863-869.
47. Gong, F., Zhang, Y., Lin, J., Li, C., Zhou, C., Hong, P., ... Ryu, B., & Qian, Z. J. (2018). 1-(5-Bromo-2-hydroxy-4-methoxyphenyl) ethanone [SE1] Inhibits MMP-9 Expression by Regulating NF-B and MAPKs Signaling Pathways in HT1080 Human Fibrosarcoma Cells. Evidence-Based Complementary and Alternative Medicine, 2018.
연구실적 (저서)
1. BoMi Ryu, You-Jin Jeon. Development of functional food products with natural materials derived from marine resources. Food Science and Industry 2019; 51, 157-164.
연구실적 (국제 및 국내특허 등록)
1. 미국특허: Jeon, Y. J., & BoMi, R. Y. U. (2021). Novel Compound Hexadecaphlorethol Isolated from Ishige Okamurae and Use Thereof. USA. Patent No. 16192216
2. 유럽특허: Jeon, Y. J., & BoMi, R. Y. U. (2020). Novel Compound Hexadecaphlorethol Isolated from Ishige Okamurae and Use Thereof. Europe. Patent No. EP18186250.9
3. 일본특허: 패 (Ishige okamurae Yendo)로부터 분리된 신규 화합물인 헤키사데카후로레토르 및 그 용도, JR, Japan. Patent No. : 2018-139945 (2019.11.29)
4. PCT출원: Novel Compound Hexadecaphlorethol Isolated From Ishige Okamurae And Use Thereof Patent No. : US10961176B2 (2021.03.30)
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1. 국내: 패 추출물 또는 디플로르에토하이드록시카르마롤을 이용한 근력 개선 또는 근위축 개선용 조성물, KR, 10-2021-0054835 (등록일: 2021.10.15)
2. 국내: 패 추출물 또는 디플로르에토하이드록시카르마롤을 이용한 노화로 인한 근감소증 개선용 조성물, KR, 10-2021-0054834 (등록일: 2021.10.15)
3. 국내: 패 추출물 또는 아이소플로로글루신 A를 이용한 근력 개선 또는 근위축 개선용 조성물, KR, 10-2020-0109571 (등록일: 2021.06.22)
4. 국내: 홍해삼 효소 가수분해물을 유효성분으로 포함하는 근육질환 치료 또는 근력개선용 약학적 조성물 및 식품 조성물, KR, 한국해양과학기술, 1020180172684
5. 국내: 패 추출물을 이용한 운동수행능력 개선용 조성물, KR, 10-2018-0139795 (2019. 12. 04)
6. 국내: 패에서 분리한 신규화합물 헥사데카플로레톨을 이용한 운동능력 개선용 조성물 KR, 10-2018-0063999 (2019. 12. 04)
7. 국내: 디플로르에토하이드록시카르마롤(Diphlorethohydroxycarmalol, DPHC)를 이용한 운동 능력 개선용 조성물, KR, 10-2018-0063998 (2018.12.27)
8. 국내: 패에서 분리한 신규 화합물 헥사데카플로레톨 및 그 화합물을 이용한 항당뇨 조성물, KR, 10-2018-0064000 (2018. 12.27)
연구실: 부경대학교 대연캠퍼스 자연과학1관(B15) 5315호 류보미교수연구실
실험실: 부경대학교 대연캠퍼스 자연과학1관(B15) 5333B호 분자생물학실험실